解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::PSMD9 (Proteasome Macropain non-ATPase subunit 9), a proteasomal assembly chaperone, harbors an uncharacterized PDZ-like domain. Here we report the identification of five novel interacting partners of PSMD9 and provide the first glimpse at the structure of the PDZ-domain, including the molecular details of the interac...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1016/j.fob.2014.05.005
更新日期:2014-06-06 00:00:00
abstract::RAC3 is a coactivator of glucocorticoid receptor and nuclear factor-κB (NF-κB) that is usually over-expressed in tumors and which also has important functions in the immune system. We investigated the role of the inflammatory response in the control of RAC3 expression levels in vivo and in vitro. We found that inflamm...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1016/j.fob.2014.04.009
更新日期:2014-05-02 00:00:00
abstract::Identification of viral encoded proteins that interact with RNA-dependent RNA polymerase (RdRp) is an important step towards unraveling the mechanism of replication. Sesbania mosaic virus (SeMV) RdRp was shown to interact strongly with p10 domain of polyprotein 2a and moderately with the protease domain. Mutational an...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1016/j.fob.2014.03.009
更新日期:2014-03-29 00:00:00
abstract::Eukaryotic protein O-mannosyltransferases (Pmts) are divided into three subfamilies (Pmt1, Pmt2, and Pmt4) and activity of Pmts in yeasts and animals requires assembly into complexes. In Saccharomyces cerevisiae, Pmt1 and Pmt2 form a heteromeric complex and Pmt 4 forms a homomeric complex. The filamentous fungus Asper...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1016/j.fob.2014.03.006
更新日期:2014-03-19 00:00:00
abstract::The pathogenic bacteria Streptococcus pyogenes can cause an array of diseases in humans, including moderate infections such as pharyngitis (strep throat) as well as life threatening conditions such as necrotizing fasciitis and puerperal fever. The antigen I/II family proteins are cell wall anchored adhesin proteins fo...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1016/j.fob.2014.02.012
更新日期:2014-03-12 00:00:00
abstract::Extensive simple sequence repeat (SSR) surveys have been performed for eukaryotic prokaryotic and viral genomes, but information regarding SSRs in viroids is limited. We undertook a survey to examine the presence of SSRs in viroid genomes. Our results show that the distribution of SSRs in viroids may influence seconda...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1016/j.fob.2014.02.001
更新日期:2014-02-07 00:00:00
abstract::In this study, it was shown for the first time that l-amino acid oxidase of Pseudomonas sp. AIU813, renamed as l-amino acid oxidase/monooxygenase (l-AAO/MOG), exhibits l-lysine 2-monooxygenase as well as oxidase activity. l-Lysine oxidase activity of l-AAO/MOG was increased in a p-chloromercuribenzoate (p-CMB) concent...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1016/j.fob.2014.02.002
更新日期:2014-02-07 00:00:00
abstract::The Wilms tumor protein 1 (WT1) transcription factor has been associated in malignant melanoma with cell survival and metastasis, thus emerging as a candidate for targeted therapy. A lysine-arginine rich peptide, WT1-pTj, derived from the ZF domain of WT1 was evaluated as an antitumor agent against A2058 human melanom...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1016/j.fob.2014.01.007
更新日期:2014-01-21 00:00:00
abstract::Cisplatin-based chemotherapy is the standard treatment of choice for head and neck squamous cell carcinoma (HNSCC). The efficiency of platinum-based therapies is directly influenced by the development of tumor resistance. Multiple signaling pathways have been linked to tumor resistance, including activation of nuclear...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1016/j.fob.2013.12.003
更新日期:2013-12-30 00:00:00
abstract::Centrins are members of the EF-hand family of calcium-binding proteins, which are highly conserved among eukaryotes. Centrins bind to several cellular targets, through a hydrophobic triad. However, the W(1)xxL(4)xxxL(8) triad in XPC (Xeroderma Pigmentosum Group C protein) is found in the reverse orientation, as in the...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1016/j.fob.2013.11.005
更新日期:2013-12-05 00:00:00
abstract::Hypoxia-inducible factor (HIF) is a crucial regulator of cellular and systemic responses to low oxygen levels. Here we firstly cloned three HIF-α isoforms from the basal branches of Osteichthyes and used computational tools to characterise the molecular change underlying the functional divergence of HIF-α isoforms in ...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1016/j.fob.2013.09.004
更新日期:2013-09-19 00:00:00
abstract::Megakaryoblastic leukemia 1 (MKL1) is a member of the MKL family of serum response factor (SRF) coactivators. Here we have identified three rat MKL1 transcripts: two are homologues of mouse MKL1 transcripts, full-length MKL1 (FLMKL1) and basic, SAP, and coiled-coil domains (BSAC), the third is a novel transcript, MKL1...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1016/j.fob.2013.09.001
更新日期:2013-09-07 00:00:00
abstract::Mediterranean Carthamus tinctorius (Safflower) is used for treatment of inflammatory conditions and neuropsychiatric disorders. Recently C. tinctorius lignans arctigenin and trachelogenin but not matairesinol were described to interfere with the activity of tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO)...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1016/j.fob.2013.08.008
更新日期:2013-09-07 00:00:00
abstract::A local tissue-specific renin-angiotensin system (local RAS) has been identified in many organs. However, no report has described the role of a local RAS in the hypertrophic differentiation of chondrocytes. To examine the role of a local RAS in the hypertrophic differentiation, we activated angiotensin II type 1 recep...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1016/j.fob.2013.07.001
更新日期:2013-07-04 00:00:00
abstract::Nisin is the most prominent and applied bacteriocin that serves as a model for class I lantibiotics. The nisin leader peptide importantly determines interactions between precursor nisin and its modification enzymes NisB and NisC that mature nisin posttranslationally. NisB dehydrates serines and threonines, while NisC ...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1016/j.fob.2013.05.001
更新日期:2013-05-30 00:00:00
abstract::The nuclear envelopes surrounding the oocyte germinal vesicles of lower vertebrates (fish and frog) are supported by the lamina, which consists of the protein lamin B3 encoded by a gene found also in birds but lost in the lineage leading to mammals. Like other members of the lamin family, goldfish lamin B3 (gfLB3) con...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1016/j.fob.2013.03.003
更新日期:2013-03-29 00:00:00
abstract::Abscisic acid (ABA) response elements (ABREs) are a group of cis-acting DNA elements that have been identified from promoter analysis of many ABA-regulated genes in plants. We are interested in understanding the mechanism of binding specificity between ABREs and a class of bZIP transcription factors known as ABRE bind...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1016/j.fob.2013.01.006
更新日期:2013-01-22 00:00:00
abstract::Mutations in the eye lens gap junction protein connexin 50 cause cataract. Earlier we identified a frameshift mutant of connexin 50 (c.670insA; p.Thr203AsnfsX47) in a family with autosomal recessive cataract. The mutant protein is smaller and contains 46 aberrant amino acids at the C-terminus after amino acid 202. Her...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1016/j.fob.2012.11.005
更新日期:2012-11-27 00:00:00
abstract::Human STIL (SCL/TAL1 interrupting locus) protein maintains centriole stability and spindle pole localisation. It helps in recruitment of CENPJ (Centromere protein J)/CPAP (centrosomal P4.1-associated protein) and other centrosomal proteins. Mutations in STIL protein are reported in several disorders, especially in der...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1016/j.fob.2012.09.003
更新日期:2012-09-25 00:00:00
abstract::Human type 2 diabetes is associated with β-cell apoptosis, and human islets from diabetic donors are ∼80% deficient in PAK1 protein. Toward addressing linkage of PAK1 to β-cell survival, PAK1-siRNA targeted MIN6 pancreatic β-cells were found to exhibit increased caspase-3 cleavage, cytosolic cytochrome-C and the pro-a...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1016/j.fob.2012.09.001
更新日期:2012-09-08 00:00:00
abstract::Transformation of fungi by complementation of auxotrophs is generally much more reliable than usage of antibiotic resistance markers. In order to establish such a system for the model zygomycete Absidia glauca, a stable methionine auxotrophic mutant was isolated after X-ray mutagenesis of the minus mating type and cha...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1016/j.fob.2012.07.002
更新日期:2012-07-20 00:00:00
abstract::Oxidative stress has been associated with prostate cancer development and progression due to an increase of reactive oxygen species (ROS). However, the mechanisms whereby ROS and the antioxidant system participate in cancer progression remain unclear. In order to clarify the influence of oxidative stress in prostate c...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1016/j.fob.2012.05.001
更新日期:2012-05-30 00:00:00
abstract::Redox-coupled folding pathways of bovine pancreatic ribonuclease A (RNase A) with four intramolecular disulfide (SS) bonds comprise three phases: (I) SS formation to generate partially oxidized intermediate ensembles with no rigid folded structure; (II) SS rearrangement from the three SS intermediate ensemble (3S) to ...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1016/j.fob.2012.04.001
更新日期:2012-04-16 00:00:00
abstract::Hsp90 is essential for maintaining the activity of numerous signaling factors, and plays a key role in cellular signal transduction networks. 17-Allylamino-17-demethoxygeldanamycin (17-AAG) is an ansamycin antibiotic that binds to Hsp90 and inhibits its function. HaCaT human keratinocytes were used to investigate the ...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1016/j.fob.2012.03.002
更新日期:2012-03-25 00:00:00
abstract::Oxidative stress in plants causes ferredoxin down-regulation and NADP(+) shortage, over-reduction of the photosynthetic electron transport chain, electron leakage to oxygen and generation of reactive oxygen species (ROS). Expression of cyanobacterial flavodoxin in tobacco chloroplasts compensates for ferredoxin declin...
journal_title:FEBS open bio
pub_type: 杂志文章
doi:10.1016/j.fob.2011.10.004
更新日期:2011-11-11 00:00:00